Neuromyelitis Optica Spectrum Profile, Serum; test site LHSC

Test Overview

Clinical Utility

This test can be used to help distinguish between Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorders (NMOSD).

A single autoantibody test is not diagnostic and should not be used to determine course of treatment. The test result must be evaluated with consideration of clinical presentation, patient history and other laboratory tests.

Method

Indirect Immunofluorescence Assay (IFA)

Result Included

Anti-AQP4; Anti-MOG

Aliases/Synonyms

Anti Myelin Oligodendrocyte Glycoprotein and Anti Aquaporin4 IgG; Anti AQP4 antibody; Anti NMO antibody; Anti MOG antibody; NMOSD

Specimen

Specimen Type

Serum
Plasma

Important Note: Neuromyelitis Optica testing is available at multiple testing labs. Non-interfaced clients should specify the Test ID NMOSP S when ordering this test. Not doing so will cause processing delays while ICL ascertains which test you are requesting.

Containers

Preferred Containers

Gold top (clot activator & gel); Red top (no additive)

Acceptable Containers

Lavender top (EDTA); Green top (lithium or sodium heparin); Blue top (3.2% buffered citrate)

Volume

Sample Volume

2 mL

Minimum Volume

1 mL

Collection & Handling

Handling Information

Store and send frozen. Avoid freeze/thaw cycles.

Additional Information

MOG titer is performed when MOG is positive at no additional fee.

Stability

Refrigerated	Frozen
14 days	30 days

Avoid freeze/thaw cycles.

Performance & Interpretation

Turnaround Time

7 days

Results

Anti-AQP4,S

Negative
Anti-MOG,S

Negative

Sample Report

Neuromyelitis Spectrum Profile, Serum.

Interface & Setup

HL7 Interface Codes

Order Code	Result Name	Result Codes
NMOSP S	Anti-AQP4,S	63525
	Anti-MOG,S	63526
	NMOSD Antibody Result	66095

Test Version

Last Updated

2025-04-15