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Test ID:
LCFAT
Long Chain Fatty Acids, Serum/Plasma
Orderable by Ontario ND
Test Overview
Clinical Utility
This is a screening test for X-linked adrenoleukodystrophy. Affected males will have elevated parameters. Heterozygous females usually have elevated parameters, but they are often in the upper normal range. Other peroxisomal diseases may also be detected by this test (elevated parameters).
Method
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Result Included
C26:0; C26:0/C22:0 ratio; C24:0/C22:0 ratio; Interpretation
Aliases/Synonyms
LCFA; VLCFA; Very Long Chain Fatty Acids
Specimen
Containers
Collection Containers
Gold top (clot activator & gel); Lavender top (EDTA)
Volume
Sample Volume
2 mL
Minimum Volume
1.5 mL
Patient Preparation
Fasting specimen is preferred.
Collection & Handling
Collection Instructions
Collect fasting specimen.
Handling Information
Separate and freeze as soon as possible. Store and send frozen.
Stability
| Refrigerated | Frozen |
|---|---|
| 7 days | > 7 days |
Performance & Interpretation
Turnaround Time
15 days
Results
Name
Units
Reference Range
Conversion
-
C26:0µmol/L≤ 0.800
-
C26:0/C22:0 ratioRatio≤ 0.0134
-
C24:0/C22:0 ratioRatio≤ 1.260
-
Interpretation
Sample Report
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| LCFAT | C26 | 3802 | umol/L |
| C26/C22 Ratio | 3803 | ||
| C24/C22 Ratio | 3804 | ||
| LCFA Interp | 3805 |
Test Version
Last Updated
2024-02-09