Collagen Cross-Linked N-Telopeptide (NTx), 24 hr Urine
Test Overview
Clinical Utility
NTx is useful to assess bone resorption in patients with metabolic bone disease and monitor therapy to slow or halt osteoporotic bone loss. A decline of 30% or more of NTx over a six-month period suggests effective therapy.
Method
Chemiluminescence (CL)
Result Included
N-Telopeptide; Creatinine
Aliases/Synonyms
Ntelopeptide
Specimen
Specimen Type
Urine (24hr)Containers
Collection Containers
Sterile Container
Volume
Sample Volume
2 mL
Minimum Volume
1 mL
Collection & Handling
Collection Instructions
Do not include first morning specimen; collect all subsequent voidings. The last sample collected should be the first morning specimen voided the following morning at the same time as the previous morning’s first voiding.
Handling Information
Specify 24-hour total volume on aliquot container and test requisition. Store and send frozen.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| 3 days | 5 days | 30 days |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Specimen | Preserved |
Performance & Interpretation
Turnaround Time
6 days
Results
-
N-Telopeptide, 24 hr UrinenM BCE/mM creatMale:
18 - 29 y: 5 - 88
30 - 39 y: 7 - 51
40 - 49 y: 5 - 47
50 - 60 y: 6 - 43
Female:
Premenopausal: 5 - 79
Comment
Results are primarily used for monitoring the response to therapy. A value within the premenopausal reference range does not rule out osteoporosis nor the need for therapy.
-
Creatinine, 24-Hour Urineg/24 h< 3 y: Not established
3 - 8 y: 0.10 - 0.80
9 - 12 y: 0.20 - 1.40
13 - 17 y: 0.40 - 1.90
> 17 y: 0.50 - 2.15
Referral Location
Out-of-Country
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| NTELOPEP U | Total Volume | 64479 | mL |
| N-Telopeptide (NTx), 24 U | 65193 | nM BCE/mM creat | |
| Creatinine, 24-hour Urine | 65194 | MG/24 hr |
Test Version
Last Updated
2023-09-01