Glucose-6-phosphate dehydrogenase (G6PD), Whole Blood
Orderable by Ontario ND
Test Overview
Clinical Utility
G6PD activity is used for identifying G6PD deficiency that can be asymptomatic or underlie acute hemolytic anemias and chronic hemolysis. G6PD deficiency is an X-linked disorder caused by mutations in the G6PD gene. This condition can be asymptomatic, although patients can present with chronic hemolysis or episodic anemia following exposure to infections, fava beans or drugs (Higgins V. JALM 2021). However, transfusion of red blood cell products less than 3 months prior to testing, significantly elevated reticulocytes and significantly elevated leukocyte counts, can falsely elevate G6PD levels. In neonates where there is a strong clinical suspicion of G6PD deficiency, retesting in 3 months and/or referral to a paediatric haematologist for further evaluation may be warranted.
Method
Spectrophotometry - kinetic
Analytical Platform
Alinity c
Result Included
Glucose-6-Phosphate dehydrogenase
Aliases/Synonyms
G-6PD; G-6-PD; Glucose 6 phosphate dehydrogenase
Specimen
Specimen Type
BloodContainers
Preferred Containers
Yellow top (ACD)
Acceptable Containers
Lavender top (EDTA)
Volume
Sample Volume
3 mL
Minimum Volume
1 mL
Collection & Handling
Handling Information
Do not freeze. Store and send cold.
Stability
| Refrigerated | Frozen |
|---|---|
| 10 days | Unacceptable |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Specimen | Frozen |
Performance & Interpretation
Turnaround Time
7 days
Results
-
Glucose-6-Phosphate DehydrogenaseU/g Hb7.0 - 18.0
Comment
Transfusion of red blood cell products less than 3 months prior to testing, significantly elevated reticulocytes and significantly elevated leukocyte counts, can falsely elevate G6PDlevels.
In neonates where there is a strong clinical suspicion of G6PD deficiency, retesting in 3 months and/or referral to a paediatric haematologist for further evaluation may be warranted
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| G6PD | Glucose-6-P-dehydrogenase | 2960 | U/g Hb |
Test Version
Last Updated
2023-01-13