Test Overview
Clinical Utility
Adenosine Deaminase (ADA) deficiency is an autosomal recessive disorder of purine metabolism primarily affecting lymphocyte development, viability, and function. Affected individuals have less than 1 percent of normal ADA catalytic activity in red cell hemolysates. ADA deficiency is the cause of 20-30 percent of SCID cases. If the patient has been recently transfused, ADA deficiency may be masked; interpret results with caution. Heterozygotes cannot be identified by this test.
Method
Spectrophotometry - kinetic
Aliases/Synonyms
ADA Deficiency
Specimen
Specimen Type
Whole BloodContainers
Collection Containers
Lavender top (EDTA); Pink top (EDTA); Green top (Li heparin)
Volume
Sample Volume
1.0 mL
Minimum Volume
1.0 mL
Collection & Handling
Handling Information
Store and send cold; do not freeze.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| 15 days | 15 days | Not acceptable |
Rejection Criteria
| Criteria | Specification |
|---|---|
| Hemolysis | Present |
| Specimen | Frozen |
Performance & Interpretation
Turnaround Time
10 days
Results
Name
Units
Reference Range
Conversion
-
Adenosine DeaminasemU/g Hb400 - 900
Referral Location
Out-of-Country
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| ADA ERC | ADENOSINE DEAMINASE RBC | 63375 | mU/g Hb |
Test Version
Last Updated
2022-06-24