Share to
Share to
Test ID:
GANGM S
Gangliosides Antibodies Profile IgG and IgM, Serum
Test Overview
Clinical Utility
TABLE 1: Anti-Gangliosides Associations:
| Antibodies Against | Ig Class | Associated Neuropathies |
|---|---|---|
| GM1, GD1a, GD1b and GT1b | IgM | Multifocal motor neuropathy (MMN) |
| GM2 and GM3 | IgM, IgG | Multifocal motor neuropathy (MMN) |
| GM3, GD1a and GT1b | IgM | Guillain-Barré syndrome (GBS) |
| GM1, GM2, GD1b, GQ1b | IgM, IgG | Guillain-Barré syndrome (GBS) |
| GM2, GD1a and GD1b | IgM | Chronic inflammatory demyelinating polyneuropathy (CIDP) |
| GM3 | IgM, IgG | Chronic inflammatory demyelinating polyneuropathy (CIDP) |
| GQ1b | IgG | Miller-Fisher syndrome (MFS) |
| GD1b | IgG | Sensory neuropathy |
Method
Immunoblot
Analytical Platform
EUROImmun EUROBlotOne
Result Included
Anti GM1 IgG; Anti GM2 IgG; Anti GM3 IgG; Anti GD1a IgG; Anti GD1b IgG; Anti GT1b IgG; Anti GQ1b IgG; Anti GM1 IgM; Anti GM2 IgM; Anti GM3 IgM; Anti GD1a IgM; Anti GD1b IgM; Anti GT1b IgM; Anti GQ1b IgM
Aliases/Synonyms
Anti GM1 IgG, Anti GM2 IgG, Anti GM3 IgG, Anti GD1a IgG, Anti GD1b IgG, Anti GT1b IgG, Anti GQ1b IgG, Anti GM1 IgM, Anti GM2 IgM, Anti GM3 IgM, Anti GD1a IgM, Anti GD1b
Specimen
Specimen Type
SerumPlasma
Containers
Preferred Containers
Serum (Red Top)
Acceptable Containers
Plasma (EDTA, Heparin or Citrate)
Volume
Sample Volume
1.0 mL
Minimum Volume
0.5 mL
Collection & Handling
Handling Information
Store and send frozen.
Stability
| Refrigerated | Frozen |
|---|---|
| 14 days | 30 days |
Performance & Interpretation
Turnaround Time
22 days
Results
Name
Units
Reference Range
Conversion
-
Anti GM1 IgGNegative
Comment
Immunoblot results will be reported as either negative or positive for specific antibodies:
(+) Borderline
1+ Weak Positive
2+ Positive
3+ Strong PositiveTABLE 1: Anti-Gangliosides Associations:
Antibodies Against Ig Class Associated Neuropathies GM1, GD1a, GD1b and GT1b IgM Multifocal motor neuropathy (MMN) GM2 and GM3 IgM, IgG Multifocal motor neuropathy (MMN) GM3, GD1a and GT1b IgM Guillain-Barré syndrome (GBS) GM1, GM2, GD1b, GQ1b IgM, IgG Guillain-Barré syndrome (GBS) GM2, GD1a and GD1b IgM Chronic inflammatory demyelinating polyneuropathy (CIDP) GM3 IgM, IgG Chronic inflammatory demyelinating polyneuropathy (CIDP) GQ1b IgG Miller-Fisher syndrome (MFS) GD1b IgG Sensory neuropathy -
Anti GM2 IgGNegative
-
Anti GM3 IgGNegative
-
Anti GD1a IgGNegative
-
Anti GD1b IgGNegative
-
Anti GT1b IgGNegative
-
Anti GQ1b IgGNegative
-
Anti GM1 IgMNegative
-
Anti GM2 IgMNegative
-
Anti GM3 IgMNegative
-
Anti GD1a IgMNegative
-
Anti GD1b IgMNegative
-
Anti GT1b IgMNegative
-
Anti GQ1b IgMNegative
Referral Location
Canada
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| GANGM S | Anti GM1 IgG | 63208 | |
| Anti GM2 IgG | 63209 | ||
| Anti GM3 IgG | 63210 | ||
| Anti GD1a IgG | 63211 | ||
| Anti GD1b IgG | 63212 | ||
| Anti GT1b IgG | 63213 | ||
| Anti GQ1b IgG | 63214 | ||
| Anti GM1 IgM | 63215 | ||
| Anti GM2 IgM | 63216 | ||
| Anti GM3 IgM | 63217 | ||
| Anti GD1a IgM | 63218 | ||
| Anti GD1b IgM | 63219 | ||
| Anti GT1b IgM | 63220 | ||
| Anti GQ1b IgM | 63221 |
Test Version
Last Updated
2024-07-25