Test Overview
Clinical Utility
The presence of Human Anti-mouse Antibody (HAMA) has been associated with patients receiving injections of Murine Monoclonal Antibody (MAB) for diagnostics and/or therapeutic purposes. HAMA produced in response to monoclonal antibody therapy may interfere with therapeutic efficacy. Therefore, it is recommended that baseline HAMA levels are determined prior to the initiation of therapy with murine-derived proteins.
Method
Enzyme-linked immunosorbent assay (ELISA)
Result Included
Human Anti-Mouse Antibody (HAMA)
Specimen
Specimen Type
Avoid gel separator tubesSerum
Containers
Preferred Containers
Serum red top (no gel)
Volume
Sample Volume
1.0 mL
Minimum Volume
0.5 mL
Specimen Comment
Avoid gel separator tubes.
Collection & Handling
Handling Information
Store and send frozen.
Stability
| Ambient | Refrigerated | Frozen |
|---|---|---|
| Unacceptable | 24 hours | 21 days |
Frozen -70°C: 90 days
Rejection Criteria
| Criteria | Specification |
|---|---|
| Specimen | Gel-separator tube |
| Lipemia | Gross |
Performance & Interpretation
Turnaround Time
15 days
Results
Name
Units
Reference Range
Conversion
-
Human Anti-Mouse Antibody (HAMA)ng/mL≤74
Referral Location
Out-of-Country
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| HAMA | HUMAN ANTI MOUSE ANTIBODY (HAMA) | 62411 | ng/mL |
Test Version
Last Updated
2023-06-13