Test Overview
Clinical Utility
Therapeutic Drug Monitoring (TDM) of pyrazinamide is used to optimize dosing, ensuring efficacy while minimizing toxicity. Pyrazinamide is a first-line anti-tuberculosis (TB) drug, primarily effective against Mycobacterium tuberculosis.
Method
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Result Included
Pyrazinamide Level
Specimen
Specimen Type
SerumContainers
Collection Containers
Red top (no additive)
Volume
Sample Volume
2.0 mL
Minimum Volume
0.5 mL
Collection & Handling
Handling Information
Allow to clot for 30 minutes, separate serum from cells immediately by centrifugation and aliquot into a labeled polypropylene or similar plastic tube. Store and send frozen.
Stability
| Ambient | Frozen |
|---|---|
| 24 hours | > 24 hours |
Freeze at -70C if possible, but at minimum -20C.
Rejection Criteria
| Criteria | Specification |
|---|---|
| Specimen | Thawed samples for greater than 24 hours |
Performance & Interpretation
Turnaround Time
14 days
Results
Name
Units
Reference Range
Conversion
-
See report
Referral Location
Out-of-Country
Interface & Setup
HL7 Interface Codes
| Order Code | Result Name | Result Codes | Units |
|---|---|---|---|
| PYRAZINL SP | Pyrazinamide Level | 65035 | mcg/mL |
Test Version
Last Updated
2025-11-19